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TREATING YOUR DEPRESSION

How can depression be treated?

Even in the most severe cases, depression can be treated. The most common forms of treatment are antidepressants and psychotherapy.

Antidepressants can be used to help relieve your depression symptoms. However, it is important to note that each person has unique needs and concerns. So, an antidepressant medication that may work well for your friend or family member may not work well for you.

The most common types of antidepressants are SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin and norepinephrine reuptake inhibitors). SSRIs are thought to work by affecting the chemical serotonin in the brain. SNRIs are thought to work by increasing the level of 2 chemicals in the brain: serotonin and norepinephrine.

With psychotherapy, a trained and licensed professional will use verbal communication and a variety of other techniques to treat the emotional and behavioral aspects of depression. It can help patients cope with their problems and understand the effects that depression has on them.

There are many factors that determine the best course of treatment for you, and only a healthcare professional can diagnose and treat depression. Here are several tips to help you get the most out of your treatment.

  • Follow through. Attending therapy or taking FETZIMA® will not help if it is done sporadically. Always take FETZIMA as prescribed, and never stop taking your medication without talking to your doctor first.
  • Follow up. Make appointments with your doctor to discuss how your treatment is going. Discuss any improvements, as well as any side effects that you may be experiencing. It is important to make this an open discussion.
  • Learn more by taking advantage of the different resources at your disposal. Visit our Tools & Resources section for a list of helpful materials and contacts.
  • Exercise as much as you can. Even if it’s just a 30-minute walk, exercise can have a positive effect on a person’s mood.
  • Be around other people. Make a conscious effort to leave the house, even if you aren’t feeling up to it. Trips to the mall, movies, or a friend’s house can help. Don’t let depression dictate your behavior.

FETZIMA INDICATION AND USAGE

FETZIMA (levomilnacipran) extended-release capsules is a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for the treatment of Major Depressive Disorder (MDD) in adults.

FETZIMA is not approved for the management of fibromyalgia, and its efficacy and safety have not been established for that use.

IMPORTANT RISK INFORMATION

What is the most important information I should know about depression, antidepressant medicines, other serious mental illnesses, suicidal thoughts or actions and serotonin syndrome?

FETZIMA and other antidepressant medicines may cause serious side effects.

WARNING: SUICIDAL THOUGHTS AND BEHAVIORS

Antidepressants increased the risk of suicidal thoughts and behavior in children, teenagers, and young adults.

In patients of all ages who are started on antidepressant therapy, watch closely for worsening depression and for suicidal thoughts and behaviors. Families and caregivers of patients on antidepressants should talk with the patient's doctor if depression becomes worse.

FETZIMA is not approved for use in patients under 18.

Call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

Serotonin Syndrome: A rare, but potentially life-threatening condition can happen when medicines such as FETZIMA are taken with certain other medicines. Serotonin syndrome can cause serious changes in how your brain, muscles, heart and blood vessels, and digestive system work. Symptoms of serotonin syndrome may include: agitation; hallucinations; coma or other changes in mental status; coordination problems or muscle twitching; fast heartbeat; high or low blood pressure; sweating or fever; nausea; vomiting or diarrhea; or muscle stiffness or tightness

Who should not take FETZIMA?

DO NOT take FETZIMA if you:

What should I tell my healthcare provider before taking FETZIMA?

Tell your healthcare provider if you:
Tell your healthcare provider about all prescription, over-the-counter medicines, vitamins and herbal supplements you are taking or plan to take, especially:

What should I avoid while taking FETZIMA?

What are the possible side effects of FETZIMA?

FETZIMA may cause serious side effects, including:
The most common side effects of FETZIMA include:

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of FETZIMA. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects.


Please also see the Medication Guide within the full Prescribing Information.


IMPORTANT RISK INFORMATION

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FETZIMA INDICATION AND USAGE

FETZIMA (levomilnacipran) extended-release capsules is a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for the treatment of Major Depressive Disorder (MDD) in adults.

FETZIMA is not approved for the management of fibromyalgia, and its efficacy and safety have not been established for that use.

IMPORTANT RISK INFORMATION

What is the most important information I should know about depression, antidepressant medicines, other serious mental illnesses, suicidal thoughts or actions and serotonin syndrome?

FETZIMA and other antidepressant medicines may cause serious side effects.

WARNING: SUICIDAL THOUGHTS AND BEHAVIORS

Antidepressants increased the risk of suicidal thoughts and behavior in children, teenagers, and young adults.

In patients of all ages who are started on antidepressant therapy, watch closely for worsening depression and for suicidal thoughts and behaviors. Families and caregivers of patients on antidepressants should talk with the patient's doctor if depression becomes worse.

FETZIMA is not approved for use in patients under 18.

Call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:
  • Attempts to commit suicide; acting on dangerous impulses; acting aggressive; being angry or violent; thoughts about suicide or dying; new or worsening depression or anxiety; feeling very agitated or restless; panic attacks; trouble sleeping; new or worsening irritability; an extreme increase in activity or talking (mania); or other unusual changes in behavior or mood

Serotonin Syndrome: A rare, but potentially life-threatening condition can happen when medicines such as FETZIMA are taken with certain other medicines. Serotonin syndrome can cause serious changes in how your brain, muscles, heart and blood vessels, and digestive system work. Symptoms of serotonin syndrome may include: agitation; hallucinations; coma or other changes in mental status; coordination problems or muscle twitching; fast heartbeat; high or low blood pressure; sweating or fever; nausea; vomiting or diarrhea; or muscle stiffness or tightness

Who should not take FETZIMA?

DO NOT take FETZIMA if you:
  • Are allergic to levomilnacipran, milnacipran HCl, or any of the ingredients in FETZIMA
  • Have taken any drugs known as monoamine oxidase inhibitors (MAOIs) within the last 14 days, including the antibiotic linezolid or intravenous methylene blue

What should I tell my healthcare provider before taking FETZIMA?

Tell your healthcare provider if you:
  • Have high blood pressure or tend to have a fast heart rate
  • Have heart or kidney problems
  • Have or had bleeding problems. FETZIMA may increase your risk of bleeding or bruising
  • Have or had trouble urinating
  • Have or had mania, bipolar disorder (manic depression), seizures or convulsions
  • Have low salt (sodium) levels in your blood
  • Drink alcohol
  • Are pregnant, nursing, or are planning to become pregnant or to breastfeed
Tell your healthcare provider about all prescription, over-the-counter medicines, vitamins and herbal supplements you are taking or plan to take, especially:
  • Triptans used to treat migraine headaches; medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, buspirone, amphetamines, or antipsychotics; tramadol, fentanyl; over-the-counter supplements such as tryptophan or St. John's Wort, to avoid a potentially life-threatening condition
  • Aspirin, non-steroidal anti-inflammatory drug (NSAID) pain relievers, or blood thinners (eg, warfarin, Coumadin®, or Jantoven®) because they may increase the risk of bleeding
  • Diuretics (water pills)

What should I avoid while taking FETZIMA?

  • Until you know how FETZIMA affects you, you should not drive, operate heavy machinery, or engage in other dangerous activities
  • Avoid drinking alcohol while taking FETZIMA

What are the possible side effects of FETZIMA?

FETZIMA may cause serious side effects, including:
  • High blood pressure and/or increased heart rate
  • Abnormal bleeding: FETZIMA and other antidepressant medicines may increase your risk of bleeding or bruising, especially if you take blood thinners (eg, warfarin, Coumadin, or Jantoven), a non-steroidal anti-inflammatory drug (NSAID), or aspirin
  • Visual problems: Eye pain; changes in vision; swelling or redness in or around the eye. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are
  • Trouble urinating
  • Hypomania (manic episodes): Greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability, or talking more or faster than usual
  • Seizures or convulsions
  • Discontinuation symptoms: Do not stop FETZIMA without first talking to your healthcare provider. Stopping FETZIMA suddenly may cause serious symptoms, including: anxiety; irritability; high or low mood; feeling restless or sleepy; headache; sweating; nausea; dizziness; electric shock-like sensations; tremor; or confusion
  • Low salt (sodium) levels in the blood: Symptoms may include headache, difficulty concentrating, memory changes, confusion, weakness, and unsteadiness on your feet. Severe or sudden cases may produce hallucinations (seeing or hearing things that are not real), fainting, seizures, and coma. If not treated, severe low sodium levels could cause death. Elderly people may be at greater risk
The most common side effects of FETZIMA include:
  • Nausea or vomiting, constipation, sweating, increased heart rate, erectile dysfunction, and palpitations

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of FETZIMA. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects.


Please also see the Medication Guide within the full Prescribing Information.